Chronic lymphocytic leukemia, or CLL, is the most common adult leukemia in the West. It is documented as a biologically and clinically heterogeneous malignancy with varying clinical outcome.
A remarkable phenomenon in CLL is the presence of numerous subsets of patients with highly similar, or stereotyped, B cell receptors (BcR) – or “CLL subsets”, which we reported as involving one in three cases in the studied cohort. These subsets are mainly defined by a high amino acid identity within the complementarity-determining region 3 (CDR3), the main determinant of antigen specificity. Currently, there are nineteen (19) CLL subsets with 20 cases or more, which we have termed ‘major’.
This conceptual approach places CLL subsets at the center of patient stratification and offers to identify reliable associations with any aspect of CLL, from genetics to clinical evolution, response to treatment, and mechanisms of resistance.

The Encyclopedia of CLL Subsets is a unique knowledgebase on these usefully homogeneous groups of CLL patients.
Around it, layers of novel bioinformatics solutions enable researchers and clinicians alike to tap into this reference resource to get insights, link their data robustly, collaborate productively.

treemap overview grouped by...

DESCRIPTION: major and minor subsets, and the heterogeneous cohort, organised as an interactive map
NOTE: by default, the placement of subsets is random, and therefore any conclusions apart from relative sizes is not relevant
- but, select e.g. 'mutational status' from the widget and subsets are organised per such category,
  in this case 'unmutated' and 'mutated'
- then double-clicking on subsets zooms in, and hovering-over will show you such categories, then you can zoom in again...